Comparision of Different Doses of CIS Atracurium Versus Atracurium During General Anaesthesia for Abdominal Surgeries

Indian Journal of Applied Basic Medical Sciences
Year: 2019, Volume: 21(B), Issue. (2)
First page: (258) Last page: (268)
Online ISSN: 2249-7935
Print ISSN: 0975-8917
doi:

Comparision Of Different Doses Of Cis Atracurium Versus Atracurium During General  Anaesthesia For Abdominal Surgeries
Nipa N Desai1*,Vedanshi Desai2, Jagruti Satasia3, tpal4
1Assistant professor, 22ndyr resident, 3Associate  professor,  41styr resident, Department of Anesthesiology, SMT SCL Hospital, Smt NHL Municipal medical college, Ahmedabad
Corresponding author email id:drnipadesai@yahoo.co.in
vedanshi11@yahoo.co.in2
jagruti.satasia@jicindia.org3

Online Published on 02-Jul-2019

ABSTRACT

BACKGROUND: Cis- atracurium in clinical practice is devoid of histamine-induced cardiovascular effects. But it requires larger doses to create satisfactory intubating conditions such as those seen with equipotent doses of atracurium. The recommended intubating dose of cis-atracurium is 0.15mg/kg. OBJECTIVES: . In our study we will compare different doses of cis-atracurium versus atracurium. during general anaesthesia for abdominal surgeries. MATERIALS AND METHODS: Randomized control trial was done to compare between atracurium (0.5mg/kg) and different doses of cisatracurium (0.1mg/kg,0.2mg/kg,0.3mg/kg) regarding onset time, duration of action, condition of intubation, hemodynamic effects, and signs of histamine release clinically. Eighty patients were randomly assigned to one of four groups, the first group (group A) received 0.5mg/kg dose of atracurium, groupB received 0.1mg/kg dose of cisatracurium, group C received 0.2mg/kg dose of cisatracurium, while group D received 0.3mg/kg doseof cisatracurium. RESULTS: There was significant increase in heart rate and blood pressure post intubation with 0.5mg/kg dose of atracurium in group A and with 0.1 mg/kg dose of cis atracurium in group B but after 5 -10 min there was no significant increase with administration of 0.2mg/kg and 0.3mg/kg doses of cisatracurium in groups C and D respectively. Onset time was significantly lower with group A than with group B. At the same time, higher doses of cisatracurium showed low onset time and longer duration of action which was significantly lower then with group A and B. Only 0.3mg/kg dose of cis atracurium showed excellent intubating condition as compared to atracurium. 0.5mg/kg dose of atracurium and 0.1mg/kg dose of cis-atracurium were similar, while group C and group D were significantly better than group A and Group B. CONCLUSION:. Atracurium is more effective neuromuscular blocking agent than cisatracurium with the same dose, while higher doses of cisatracurium provide more effective and rapid neuromuscular blockage with longer duration of action, stable hemodynamic status, and no signs of histamine release clinically.

Keywords

Cisatracurium, Atracurium , Neuromuscular Block, Heart Rate And Blood Pressure.

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